Search Result

Search Results for " er α "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T22767	ER 50891		Retinoid Receptor
	ER-50891 is a potent retinoic acid receptor alpha (RARα) antagonist. er-50891 reduces the inhibitory effect of allosteric retinoic acid and restores osteoblast differentiation induced by bone morphogenetic protein 2.		Retinoid Receptor
T38894	IHVR-17028		Influenza Virus , Glucosidase
	IHVR-17028 is a potent broad-spectrum ERα-glucosidase I (α-glucosidase? I) inhibitor with IC50 of 0.24 μM and antiviral activity. IHVR-17028 inhibited BVDV, TCRV and DENV, and EC50 values were 0.4 μM, 0.26 μM and 0.3 μM,...		Influenza Virus , Glucosidase
T70031	ER-38925
	ER-38925 is a retinoic acid receptor (rar) subtype α-selective agonist
T13700	GDC-0927 Racemate	SRN-927 Racemate	Others
	GDC-0927 Racemate is a degrader of estrogen receptor, is used in the research of ER-related diseases, potently inhibits ER-α activity, with an IC50 of 0.2 nM.		Others
T15554	IHVR-19029		Others
	IHVR-19029 is an effective endoplasmic reticulum (ER) α-glucosidases I and II inhibitor (IC50: 0.48 μM for ER a-glucosidase I). IHVR-19029 efficiently blocks the replication of several hemorrhagic fever viruses, such as ...		Others
T40166	Bexirestrant
	Bexirestrant is an orally active ER-α degrader commonly employed in the research of antiestrogen and antineoplastic therapies.
T27590	IHVR-11029	IHVR 11029
	IHVR-11029 is a potent inhibitor of ER α-glucosidase. IHVR-11029 is active against multiple hemorrhagic fever viruses and efficiently disrupts the morphogenesis of a broad spectrum of enveloped viruses.
T78102	ER 50891 quarterhydrate
	ER 50891 quarterhydrate is a potent RARα (retinoic acid receptor α) antagonist that markedly diminishes the inhibitory effects of ATRA (all-trans retinoic acid) on osteoblastogenesis induced by BMP 2 (bone morphogenetic ...
T79382	ER degrader 6		Estrogen Receptor/ERR
	ER degrader 6 (compound 35s) is a potent selective estrogen receptor modulator (SERM) with the capacity to degrade Estrogen Receptor (ER)α. It disrupts the microtubule network, inhibiting tubulin polymerization, and effe...		Estrogen Receptor/ERR
T62793	EB-0150
	EB-0150 is a potent inhibitor of ER α-glucosidase (α-Glu) I (IC50s: 0.73 μM) and (α-Glu) II (IC50s: 0.0337 μM). EB-0150 is an N-substituted valerian derivative with broad-spectrum antiviral effects. EB-0150 has potential...
T18697	SNIPER(ER)-87		Others
	SNIPER(ER)-87 is a chemical compound composed of a derivative of the inhibitor of apoptosis protein (IAP) ligand LCL161 conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen using a PEG linker. It effecti...		Others
T63303	EB-0176
	EB-0176 is an N-substituted valerian derivative that exhibits broad-spectrum antiviral activity and is a potent ER α-glucosidase (α-Glu) I and II inhibitor with IC50s of 0.6439 and 0.0011 μM, respectively.EB-0176 exhibit...
T61923	ERRα antagonist-2
	ERRα antagonist-2 (Compound 11) is a potential Reverse agonist of ERR α (estrogen receptor related receptor α) (IC50=0.80 μ M). ERRα antagonist-2 can inhibit the migration and invasion of ER-negative MDA-MB-231 cells. ER...
T27050	CM-10-18	CM-1018
	CM-10-18 is a potent inhibitor of ER α-glucosidase. CM-10-18 demonstrated superior in vitro antiviral activity against representative viruses from four viral families causing hemorrhagic fever. CM-10-18 efficiently prote...
T62818	LSD1/ER-IN-1
	LSD1/ER-IN-1 (compound 11g) is a potent inhibitor of ER and LSD1 that acts on LSD1 (IC50: 1.55 μM). LSD1/ER-IN-1 showed good anti-proliferative effect on MCF-7 breast cancer cells (IC50: 8.79 μM).
T63170	EB-0156
	EB-0156 is a potent inhibitor of ER α-glucosidase (α-Glu) I and II with IC50 values of 0.0479 and <0.001 μM, respectively. EB-0156 is an N-substituted valerian derivative with broad-spectrum antiviral activity. EB-0156 h...
T28275	OUP-186	OUP186
	OUP-186 is a high affinity and human/rat species-selective antagonist of histamine H3 receptor. OUP-186 suppressed the proliferation of breast cancer cells. The IC50 values at 48 hours for OUP-186 was approximately 50 μM...
T61690	MEH-IN-1
	mEH-IN-1 (Compound 62) is a potent inhibitor of microsomal epoxide hydrolase (mEH), with an IC50 value of 2.2 nM. mEH is an α/β-fold hydrolase enzyme that is widely expressed in various mammalian tissues, responsible for...
T35676	17β-hydroxy Exemestane
	17β-hydroxy Exemestane is the primary active metabolite of exemestane . It is formed by metabolism of exemestane by the cytochrome P450 (CYP) isoforms CYP1A and CYP4A11. 17β-hydroxy Exemestane is an aromatase inhibitor (...

Compounds

ER 50891

T22767

Synonym:

Target: Retinoid Receptor

IHVR-17028

T38894

Synonym:

Target: Influenza Virus, Glucosidase

Synonym: SRN-927 Racemate

ER 50891 quarterhydrate

Target: Estrogen Receptor/ERR

17β-hydroxy Exemestane

T35676

Synonym:

Target:

Cat No.	Product Name	Synonyms	Targets
T2930	α-Lipoic Acid	Lipoic acid,Alphalipoic acid	NF-κB , HIV Protease , Mitochondrial Metabolism , Endogenous Metabolite
	α-Lipoic Acid (Alphalipoic acid) inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells.α-Lipoic Acid is an antioxidant, which is an es...
TN3084	5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone		Estrogen Receptor/ERR , Others
	5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone showed strong anti-proliferation effect on ER-positive breast cancer MCF-7 cells in vitro, with an IC50 value of 4.41 uM. 5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-dipren...		Estrogen Receptor/ERR , Others
T72429	α-Lipoic Acid sodium	Thioctic acid sodium,DL-α-Lipoic acid sodium,Thioctic acid sodium ; (±)-α-Lipoic acid sodium ; DL-α-Lipoic acid sodium,(±)-α-Lipoic acid sodium
	α-Lipoic Acid (Thioctic acid) sodium, an essential cofactor for mitochondrial enzyme complexes, serves as an antioxidant. It suppresses NF-κB-dependent activation of HIV-1 LTR [1] [2] [3] and triggers ER (endoplasmic ret...

Natural Products

α-Lipoic Acid

T2930

Synonym: Lipoic acid,Alphalipoic acid

Target: NF-κB, HIV Protease, Mitochondrial Metabolism, Endogenous Metabolite

5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone

TN3084

Synonym:

Target: Estrogen Receptor/ERR, Others

α-Lipoic Acid sodium

T72429

Synonym: Thioctic acid sodium,DL-α-Lipoic acid sodium,Thioctic acid sodium ; (±)-α-Lipoic acid sodium ; DL-α-Lipoic acid sodium,(±)-α-Lipoic acid sodium

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-00762	ER alpha Protein, Human, Recombinant (His)	Human	E. coli
	Estrogen Receptor is a major ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. Estrogen Receptor is composed of several domains important for hormone binding, DNA binding, and a...
TMPJ-01384	MAN1B1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-α-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is invo...
TMPY-03870	EDEM2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	EDEM2, also known as C2orf31, belongs to a family of proteins involved in ER-associated degradation (ERAD) of glycoproteins. In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and ...
TMPK-00075	IFN-alpha 1/IFNA1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I o...
TMPK-00074	IFN-alpha 1/IFNA1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I o...